A Mechanometabolism Toolbox for Studying Cell Migration

KM Young, S Lopez, K Boone, M Acikel, X Gallart, CA Reinhart-King

Cold Spring Harbor Perspectives in Biology, 2025, pp. a041755

Network analysis of gene expression reveals regulators of cell viscosity and mechanical phenotype

KM Young, N Latka, R Mezencev, T Sulchek

Scientific Reports, vol. 15(1), 2025, pp. 1-18

Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness

Georgii Vasiukov, Yong Zou, Maria-Fernanda Senosain, Jamshedur SM Rahman, Sanja Antic, Katherine M Young, Eric L Grogan, Michael N Kammer, Fabien Maldonado, Cynthia A Reinhart-King, Pierre P Massion

Scientific Reports, vol. 13(1), 2023, p. 17604

Cellular mechanosignaling for sensing and transducing matrix rigidity.

Katherine M. Young, Cynthia A. Reinhart-King

Current Opinion in Cell Biology, 2023

Correlating mechanical and gene expression data on the single cell level to investigate metastatic phenotypes.

Katherine M. Young, Congmin Xu, Kelly Ahkee, R. Mezencev, Steven P Swingle, T. Yu, Ava Paikeday, Cathy S. Kim, J. Mcdonald, Peng Qiu, T. Sulchek

iScience, 2023

Label-free microfluidic isolation of functional and viable lymphocytes from peripheral blood mononuclear cells.

Abhishek Raj, Katily Ramirez, Katherine M. Young, Nicholas E. Stone, Peter Shankles, Mehdia Nadeem Rajab Ali, Anthony Malik Compton, Wilbur A. Lam, Alexander Alexeev, Todd Sulchek

Biomicrofluidics, 2023

Strain-dependent elastography of cancer cells reveals heterogeneity and stiffening due to attachment.

Wenwei Xu, Saif Kabariti, Katherine M. Young, Steven P Swingle, Alan Y. Liu, T. Sulchek

Journal of Biomechanics, 2023

Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening

Wenjun Wang, Lauren A. Hapach, Lauren A Griggs, Kyra Smart, Yusheng Wu, Paul V. Taufalele, Matthew M Rowe, Katherine M. Young, Madison E Bates, Andrew C Johnson, Nicholas Ferrell, A. Pozzi, Cynthia A. Reinhart-King

Science Advances, 2022

Phenotypic heterogeneity and cooperation in the metastatic cascade

Katherine M. Young, Cynthia A. Reinhart-King

Oncoscience, 2022

Scaling microfluidic throughput with flow-balanced manifolds to simply control devices with multiple inlets and outlets.

Katherine M. Young, Peter G. Shankles, Theresa Chen, Kelly Ahkee, Sydney Bules, T. Sulchek

Biomicrofluidics, 2022

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King

Elife, vol. 11, 2022, pp. e74433

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Guorong Li, Chanyoung Lee, A. Read, Ke Wang, I. Navarro, J. Cui, Katherine M. Young, Rahul Gorijavolu, T. Sulchek, C. Kopczynski, Sina Farsiu, J. Samples, P. Challa, C. Ethier, W. Stamer

Elife, vol. 10, 2021, pp. e60831

Label-free microfluidic enrichment of cancer cells from non-cancer cells in ascites

Nicholas E. Stone, A. Raj, Katherine M. Young, Adam P. DeLuca, F. Chrit, B. Tucker, A. Alexeev, J. McDonald, B. Benigno, T. Sulchek

Scientific Reports, 2021

Microfluidic Platform to Transduce Cell Viability to Distinct Flow Pathways for High-Accuracy Sensing.

F. Chrit, A. Raj, Katherine M. Young, Nicholas E. Stone, Peter G. Shankles, Kesiharjun Lokireddy, Christopher Flowers, E. Waller, A. Alexeev, T. Sulchek

ACS Sensors, 2021

Decreased cell stiffness enhances leukemia development and progression

Linping Hu, Fang Ni, Xinyi Wang, M. Fay, Katherine M. Young, W. Lam, T. Sulchek, C. Qu

Leukemia, 2020

Cell Mechanical and Physiological Behavior in the Regime of Rapid Mechanical Compressions that Lead to Cell Volume Change.

Anna Liu, T. Yu, Katherine M. Young, Nicholas E. Stone, S. Hanasoge, Tyler J. Kirby, Vikram Varadarajan, Nicholas W. Colonna, Janet Liu, A. Raj, J. Lammerding, A. Alexeev, T. Sulchek

Small, 2019

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.

Fang Ni, Wen‐mei Yu, Xinyi Wang, M. Fay, Katherine M. Young, Y. Qiu, W. Lam, T. Sulchek, T. Cheng, D. Scadden, C. Qu

Cell Stem Cell, 2019

Biomechanics of Endothelial Tubule Formation Differentially Modulated by Cerebral Cavernous Malformation Proteins

O. Chernaya, Anastasia Zhurikhina, Siarhei Hladyshau, William Pilcher, Katherine M. Young, Jillian Ortner, V. Andra, T. Sulchek, D. Tsygankov

iScience, 2018

Biophysical subsets of embryonic stem cells display distinct phenotypic and morphological signatures

Tom Bongiorno, Jeremy R Gura, Priyanka Talwar, Dwight M. Chambers, Katherine M. Young, D. Arafat, Gonghao Wang, Emily L Jackson-Holmes, P. Qiu, T. McDevitt, T. Sulchek

PLoS ONE, 2018