APA
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Wang, W., Hapach, L. A., Griggs, L. A., Smart, K., Wu, Y., Taufalele, P. V., … Reinhart-King, C. A. (2022). Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening. Science Advances.
Chicago/Turabian
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Wang, Wenjun, Lauren A. Hapach, Lauren A Griggs, Kyra Smart, Yusheng Wu, Paul V. Taufalele, Matthew M Rowe, et al. “Diabetic Hyperglycemia Promotes Primary Tumor Progression through Glycation-Induced Tumor Extracellular Matrix Stiffening.” Science Advances (2022).
MLA
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Wang, Wenjun, et al. “Diabetic Hyperglycemia Promotes Primary Tumor Progression through Glycation-Induced Tumor Extracellular Matrix Stiffening.” Science Advances, 2022.
BibTeX Click to copy
@article{wenjun2022a,
title = {Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening},
year = {2022},
journal = {Science Advances},
author = {Wang, Wenjun and Hapach, Lauren A. and Griggs, Lauren A and Smart, Kyra and Wu, Yusheng and Taufalele, Paul V. and Rowe, Matthew M and Young, Katherine M. and Bates, Madison E and Johnson, Andrew C and Ferrell, Nicholas and Pozzi, A. and Reinhart-King, Cynthia A.}
}
Diabetes mellitus is a complex metabolic disorder that is associated with an increased risk of breast cancer. Despite this correlation, the interplay between tumor progression and diabetes, particularly with regard to stiffening of the extracellular matrix, is still mechanistically unclear. Here, we established a murine model where hyperglycemia was induced before breast tumor development. Using the murine model, in vitro systems, and patient samples, we show that hyperglycemia increases tumor growth, extracellular matrix stiffness, glycation, and epithelial-mesenchymal transition of tumor cells. Upon inhibition of glycation or mechanotransduction in diabetic mice, these same metrics are reduced to levels comparable with nondiabetic tumors. Together, our study describes a novel biomechanical mechanism by which diabetic hyperglycemia promotes breast tumor progression via glycating the extracellular matrix. In addition, our work provides evidence that glycation inhibition is a potential adjuvant therapy for diabetic cancer patients due to the key role of matrix stiffening in both diseases.